Microbiology

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Tips from the journals of the American Society for Microbiology
( American Society for Microbiology ) The following are tips from the journals of the American Society for Microbiology: "Frog Skin May Provide Antimicrobial Peptides Effective Against Multidrug-Resistant Infections"; "Self-Administered Vaccine Patch May Protect Against Potentially Pandemic Flu Viruses"; and "New Class of Peptides May Protect Against Septic Shock."

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v • d • e

Microbiology (from Greek μῑκρος, mīkros, "small"; βίος, bios, "life"; and -λογία, -logia) is the study of microorganisms, which are unicellular or cell-cluster microscopic organisms.1 This includes eukaryotes such as fungi and protists, and prokaryotes. Viruses2 and prions, though not strictly classed as living organisms, are also studied. In short; microbiology refers to the study of life and organisms that are too small to be seen with the naked eye. Microbiology typically includes the study of the immune system, or Immunology. Generally, immune systems interact with pathogenic microbes; these two disciplines often intersect which is why many colleges offer a paired degree such as "Microbiology and Immunology".

Microbiology is a broad term which includes virology, mycology, parasitology, bacteriology and other branches. A microbiologist is a specialist in microbiology and these other topics.

Microbiology is researched actively, and the field is advancing continually. It is estimated only about one percent of all of the microbe species on Earth have been studied.3 Although microbes were directly observed over three hundred years ago, the field of microbiology can be said to be in its infancy relative to older biological disciplines such as zoology and botany.

Contents 1 History 1.1 Ancient 1.2 Modern 2 Fields 3 Benefits 4 See also 5 References 6 References 7 External links 7.1 General 7.2 Journals 7.3 Professional organizations // History Ancient

The existence of microorganisms was hypothesized for many centuries before their actual discovery. The existence of unseen microbiological life was postulated by Jainism which is based on Mahavira’s teachings as early as 6th century BCE.4. Paul Dundas notes that Mahavira asserted existence of unseen microbiological creatures living in earth, water, air and fire.5 Jain scriptures also describe nigodas which are sub-microscopic creatures living in large clusters and having a very short life and are said to pervade each and every part of the universe, even in tissues of plants and flesh of animals.6 The Roman Marcus Terentius Varro made references to microbes when he warned against locating a homestead in the vicinity of swamps "because there are bred certain minute creatures which cannot be seen by the eyes, which float in the air and enter the body through the mouth and nose and there cause serious diseases."7citation needed

In 1546 Girolamo Fracastoro proposed that epidemic diseases were caused by transferable seedlike entities that could transmit infection by direct or indirect contact, or even without contact over long distances.citation needed

However, early claims about the existence of microorganisms were speculative, and not based on any data or observation. Actual observation and discovery of microbes had to await the invention of the microscope in the 17th century.

Modern Antonie van Leeuwenhoek, known as the "father of microbiology", was the first to observe microorganisms using a microscope.

in 1676, Antonie van Leeuwenhoek first observed bacteria and other microorganisms, using a single-lens microscope of his own design.1 While Van Leeuwenhoek is often cited as the first microbiologist, Robert Hooke made the first recorded microbiological observation, of the fruiting bodies of molds, in 1665.8

The field of bacteriology (later a subdiscipline of microbiology) was founded in the 19th century by Ferdinand Cohn, a botanist whose studies on algae and photosynthetic bacteria led him to describe several bacteria including Bacillus and Beggiatoa. Cohn was also the first to formulate a scheme for the taxonomic classification of bacteria.9 Louis Pasteur and Robert Koch were contemporaries of Cohn’s and are often considered to be the founders of medical microbiology.10 Pasteur is most famous for his series of experiments designed to disprove the then widely held theory of spontaneous generation, thereby solidifying microbiology’s identity as a biological science.11 Pasteur also designed methods for food preservation (pasteurization) and vaccines against several diseases such as anthrax, fowl cholera and rabies.1 Koch is best known for his contributions to the germ theory of disease, proving that specific diseases were caused by specific pathogenic microorganisms. He developed a series of criteria that have become known as the Koch's postulates. Koch was one of the first scientists to focus on the isolation of bacteria in pure culture resulting in his description of several novel bacteria including Mycobacterium tuberculosis, the causative agent of tuberculosis.1

While Pasteur and Koch are often considered the founders of microbiology, their work did not accurately reflect the true diversity of the microbial world because of their exclusive focus on microorganisms having direct medical relevance. It was not until the late 19th century and the work of Martinus Beijerinck and Sergei Winogradsky, the founders of general microbiology (an older term encompassing aspects of microbial physiology, diversity and ecology), that the true breadth of microbiology was revealed.1 Beijerinck made two major contributions to microbiology: the discovery of viruses and the development of enrichment culture techniques.12 While his work on the Tobacco Mosaic Virus established the basic principles of virology, it was his development of enrichment culturing that had the most immediate impact on microbiology by allowing for the cultivation of a wide range of microbes with wildly different physiologies. Winogradsky was the first to develop the concept of chemolithotrophy and to thereby reveal the essential role played by microorganisms in geochemical processes.13 He was responsible for the first isolation and description of both nitrifying and nitrogen-fixing bacteria.1

Fields

The field of microbiology can be generally divided into several subdisciplines:

Microbial physiology: The study of how the microbial cell functions biochemically. Includes the study of microbial growth, microbial metabolism and microbial cell structure. Microbial genetics: The study of how genes are organized and regulated in microbes in relation to their cellular functions. Closely related to the field of molecular biology. Cellular microbiology: A discipline bridging microbiology and cell biology. Medical microbiology: The study of the pathogenic microbes and the role of microbes in human illness. Includes the study of microbial pathogenesis and epidemiology and is related to the study of disease pathology and immunology. Veterinary microbiology: The study of the role in microbes in veterinary medicine or animal taxonomy. Environmental microbiology: The study of the function and diversity of microbes in their natural environments. Includes the study of microbial ecology, microbially-mediated nutrient cycling, geomicrobiology, microbial diversity and bioremediation. Characterization of key bacterial habitats such as the rhizosphere and phyllosphere, soil and groundwater ecosystems, open oceans or extreme environments (extremophiles). Evolutionary microbiology: The study of the evolution of microbes. Includes the study of bacterial systematics and taxonomy. Industrial microbiology: The exploitation of microbes for use in industrial processes. Examples include industrial fermentation and wastewater treatment. Closely linked to the biotechnology industry. This field also includes brewing, an important application of microbiology. Aeromicrobiology: The study of airborne microorganisms. Food microbiology: The study of microorganisms causing food spoilage and foodborne illness. Using microorganisms to produce foods, for example by fermentation. Pharmaceutical microbiology: the study of microorganisms causing pharmaceutical contamination and spoil Agricultural microbiology: The study of agriculturaly important microorganisms.

(Jobs with the Center For Disease Control and Prevention requires a degree in microbiology for most positions)

Soil Microbiology: The study of those microorganisms that are found in soil. Water microbiology: The study of those microorganisms that are found in water. Generation microbiology: The study of those microorganisms that have the same characters as their parents. Nano microbiology: The study of those microorganisms at nano level. Benefits Fermenting tanks with yeast being used to brew beer This section needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (July 2007)

Whilst there are undoubtedly some who fear all microbes due to the association of some microbes with various human illnesses, many microbes are also responsible for numerous beneficial processes such as industrial fermentation (e.g. the production of alcohol, vinegar and dairy products), antibiotic production and as vehicles for cloning in higher organisms such as plants. Scientists have also exploited their knowledge of microbes to produce biotechnologically important enzymes such as Taq polymerase, reporter genes for use in other genetic systems and novel molecular biology techniques such as the yeast two-hybrid system.

Bacteria can be used for the industrial production of amino acids. Corynebacterium glutamicum is one of the most important bacterial species with an annual production of more than two million tons of amino acids, mainly L-glutamate and L-lysine.14

A variety of biopolymers, such as polysaccharides, polyesters, and polyamides, are produced by microorganisms. Microorganisms are used for the biotechnological production of biopolymers with tailored properties suitable for high-value medical application such as tissue engineering and drug delivery. Microorganisms are used for the biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharide, and polyhydroxyalkanoates.15

Microorganisms are beneficial for microbial biodegradation or bioremediation of domestic, agricultural and industrial wastes and subsurface pollution in soils, sediments and marine environments. The ability of each microorganism to degrade toxic waste depends on the nature of each contaminant. Since sites typically have multiple pollutant types, the most effective approach to microbial biodegradation is to use a mixture of bacterial species and strains, each specific to the biodegradation of one or more types of contaminants.16

There are also various claims concerning the contributions to human and animal health by consuming probiotics (bacteria potentially beneficial to the digestive system) and/or prebiotics (substances consumed to promote the growth of probiotic microorganisms).17

Recent research has suggested that microorganisms could be useful in the treatment of cancer. Various strains of non-pathogenic clostridia can infiltrate and replicate within solid tumors. Clostridial vectors can be safely administered and their potential to deliver therapeutic proteins has been demonstrated in a variety of preclinical models.18

See also

Archaea Bacteria Biochemistry Biosafety Biotechnology Environmental microbiology Eukaryote Food microbiology Genetics Immunology Important publications in microbiology Industrial microbiology Iron in microbiology List of Microbiological topics Microbial phylogenetics Medical technologist Medicine Mycology Oral microbiology Bacteriophage meetings Prokaryote Virology References ^ a b c d e f Madigan M, Martinko J (editors) (2006). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 0-13-144329-1. ^ Rice G (2007-03-27). "Are Viruses Alive?". http://serc.carleton.edu/microbelife/yellowstone/viruslive.html. Retrieved 2007-07-23. ^ Amann RI, Ludwig W, Schleifer KH (1995). "Phylogenetic identification and in situ detection of individual microbial cells without cultivation". Microbiol. Rev. 59 (1): 143–169. PMID 7535888. ^ Mahavira is dated 599 BCE - 527 BCE. See. Dundas, Paul; John Hinnels ed. (2002). The Jains. London: Routledge. ISBN 0-415-26606-8. p. 24 ^ Dundas, Paul (2002) p. 88 ^ *Jaini, Padmanabh (1998). The Jaina Path of Purification. New Delhi: Motilal Banarsidass. ISBN 81-208-1578-5. p. 109 ^ Varro on Agriculture 1, xii Loeb. ^ Gest H (2005). "The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world". Perspect. Biol. Med. 48 (2): 266–72. doi:10.1353/pbm.2005.0053. PMID 15834198. ^ Drews G (1999). "Ferdinand Cohn, a Founder of Modern Microbiology". ASM News 65 (8): 547. ^ Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9. ^ Bordenave G (2003). "Louis Pasteur (1822-1895)". Microbes Infect. 5 (6): 553–60. doi:10.1016/S1286-4579(03)00075-3. PMID 12758285. ^ Johnson J (2001). "Martinus Willem Beijerinck". APSnet. American Phytopathological Society. http://www.apsnet.org/Education/feature/TMV/intro.html. Retrieved May 2, 2010. ^ Paustian T, Roberts G (2009). "Beijerinck and Winogradsky Initiate the Field of Environmental Microbiology". Through the Microscope: A Look at All Things Small (3rd ed.). Textbook Consortia. § 1–14. http://www.microbiologytext.com/index.php?module=Book&func=displayarticle&art_id=32. Retrieved May 2, 2010. ^ Burkovski A (editor). (2008). Corynebacteria: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-30-1. http://www.horizonpress.com/cory. ^ Rehm BHA (editor). (2008). Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives. Caister Academic Press. ISBN 978-1-904455-36-3. http://www.horizonpress.com/biopolymers. ^ Diaz E (editor). (2008). Microbial Biodegradation: Genomics and Molecular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-17-2. http://www.horizonpress.com/biod. ^ Tannock GW (editor). (2005). Probiotics and Prebiotics: Scientific Aspects. Caister Academic Press. ISBN 978-1-904455-01-1. http://www.horizonpress.com/pro3. ^ Mengesha et al. (2009). "Clostridia in Anti-tumor Therapy". Clostridia: Molecular Biology in the Post-genomic Era. Caister Academic Press. ISBN 978-1-904455-38-7.

References External links At Wikiversity you can learn more and teach others about Microbiology at: The Department of Microbiology General Online lectures in microbiology University of South Carolina Microbiology Online Online Microbiology textbook Todar's Bacteriology textbook Online Medical Microbiology textbook Institute of Microbiology of the Swiss Federal Institute of Technology Journals Annual Review of Microbiology Critical Reviews in Microbiology (journal home) International Journal of Systematic and Evolutionary Microbiology Journal of Bacteriology Nature Reviews Microbiology (journal home) Springer Protocols in Microbiology Microbiology Journal Descriptions and summarys of a wide range of journals in all areas of microbiology Professional organizations Microbiology Students Portal American Society for Microbiology Society for General Microbiology Society for Industrial Microbiology v • d • e Major subfields of biology Anatomy · Astrobiology · Biochemistry · Biomechanics · Biophysics · Bioinformatics · Biostatistics · Botany · Cell biology · Chemical biology · Chronobiology · Conservation biology · Developmental biology · Ecology · Epidemiology · Evolutionary biology · Genetics · Genomics · Histology · Human biology · Immunology · Marine biology · Mathematical biology · Microbiology · Molecular biology · Mycology · Neuroscience · Nutrition · Origin of life · Paleontology · Parasitology · Pathology · Pharmacology · Physiology · Systems biology · Taxonomy · Toxicology · Zoology v • d • e Microbiology: Bacteria Pathogenic bacteria

Clinical Microbiology Made Ridiculously Simple (Medmaster) MedMaster Inc.

Bacterial disease · Coley's Toxins · Exotoxin · Lysogenic cycle

Human flora

microbiology: Definition from Answers.com
microbiology n. The branch of biology that deals with microorganisms and their effects on other living organisms
www.answers.com/topic/microbiology

Gut flora · Skin flora · Vaginal flora

Substrate preference Lipophilic · Saccharophilic Oxygen preference Aerobic (Obligate) · Anaerobic (Facultative, Obligate) · Microaerophile · Nanaerobe · Aerotolerant Structures Cell envelope

Cell membrane

Cell wall: Peptidoglycan (NAM, NAG, DAP)

Gram-positive bacteria only: Teichoic acid · Lipoteichoic acid · Endospore

Gram-negative bacteria only: Bacterial outer membrane (Porin, Lipopolysaccharide) · Periplasmic space

Mycobacteria only: Arabinogalactan · Mycolic acid Outside envelope Bacterial capsule · Slime layer · S-layer · Glycocalyx Pilus · Fimbria Composite Biofilm Shapes Bacterial cellular morphologies · L-form bacteria · Coccus (Diplococcus) · Bacillus · Coccobacillus

Linking microbial sex and virulence
( American Society for Microbiology ) Two opportunistic pathogens that were once thought to be very different have evolved some sexual reproduction and disease-causing habits that are not only similar but also suggest that in the microbial world sex and virulence are closely linked, according to a review published this week in the online journal mBio.

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)

v • d • e Microbiology: Virus Components Viral envelope · Capsid · Viral protein Viral life cycle Viral entry · Viral replication · Viral shedding · Virus latency Genetics Reassortment · Antigenic shift · Antigenic drift · Phenotype mixing Other Virus disease · Laboratory diagnosis of viral infections · Antiviral drug · Bacteriophage · Neurotropic virus · Oncovirus

M: VIR

virs (prot)

cutn/syst (hppv, hiva, infl, zoon), epon

drugJ(dnaa, rnaa, rtva, vacc)

v • d • e Microbiology: Fungus Structure Reproduction/spore

teleomorph/sexual: Zygospore · Ascospore/Ascus · Basidiospore/Basidium/Teliospore

anamorph/asexual: Sporangium · Conidium · Chlamydospore · Oidium · Pycniospores Other Hypha · Haustorium · Mycelium · Cell wall Growth patterns Dimorphic fungi · Mold · Yeast · Mushroom

M: MYC

fung, clas

fung

drug (fung)

v • d • e Microbiology: Protist Protozoa locomotion Flagellate (Flagellum) · Amoeboid (Pseudopod) · Ciliate (Cilium) Other structures/organelles Chromalveolate

Ciliates: Macronucleus · Micronucleus

Apicomplexans: Rhoptry · Apicoplast · Microneme Excavate Kinetoplastids: Kinetoplast · Glycosome Multiple groups Hydrogenosome

M: PRO

ambz, excv, chrm (strc)

ambz, excv, chrm

které ani ještě neznám Současné nově se ustavující vědecké paradigma už vidí přírodu jako komplex života jako systém komunikace jako síť výměny informací atp s 140 A nakonec jsem dospěl až k hypotéze že lidská mysl může prostřednictvím rozostřeného vědomí komunikovat s globální sítí života založeného na DNA To je však v

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Fungal threat to archived film
( Society for General Microbiology ) Microbes could be threatening our cultural heritage by degrading historic cinematographic film and even preventing some valuable footage to be archived at all. Mr. Gavin Bingley who is presenting his work at the Society for General Microbiology's autumn meeting in Nottingham today describes how fungal growth on cinema film can not only lead to deterioration ...

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Microbiology is the study of microorganisms, which are unicellular or multi ... Although much is now known in the field of microbiology, advances are being made regularly. ...
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Fungal Threat To Archived Film
Microbes could be threatening our cultural heritage by degrading historic cinematographic film and even preventing some valuable footage to be archived at all.Mr Gavin Bingley who is presenting his work at the Society for General Microbiology's autumn meeting in Nottingham today describes how fungal growth on cinema film can not only lead to deterioration of the film but may also pose a risk to ...

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Articles and blogs cover the latest advancements, classic microbiology, book reviews, infectious disease, immunology, current events and more. Join in! ...
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Why is Food Poisoning Unpredictable?
(Ivanhoe Newswire) -- Ever wonder why even if you're exposed to bacteria in your food that could cause food poisoning, you don't get sick?Now, one scientist presenting at the Society for General Microbiology's meeting says he's uncovered some clues. According to Professor Colin Hill, bacteria use different "tricks" to help them survive inside the body.One of the biggest problems for ...

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'Wee Beasties'
Improbable Research points to a " stop-motion history of microbiology " at YouTube. The video's producers, at Rev Men Studios, used Lego toys to animate the educational content. A character donning a monocle narrates the stories of Antony van Leeuwenhoek and Louis Pasteur.

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Yeast Holds Clues To Parkinson's Disease
Yeast could be a powerful ally in the discovery of new therapeutic drugs to treat Parkinson's disease says a scientist presenting his work at the Society for General Microbiology's autumn meeting in Nottingham today. Dr Tiago Fleming Outeiro from the Instituto de Medicina Molecular in Lisbon, Portugal describes how his group is slowly uncovering the molecular basis of Parkinson's disease by ...

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microbiology - definition of microbiology by the Free Online ...
Translations of microbiology. microbiology synonyms, microbiology antonyms. Information about microbiology in the free online English ...
www.thefreedictionary.com/microbiology

Interrupting death messages to treat bone disease
( Society for General Microbiology ) A surface molecule on bacteria that instructs bone cells to die could be the target for new treatments for bone disease, says a scientist speaking at the Society for General Microbiology's autumn meeting today. Blocking the death signal from bacteria could be a way of treating painful bone infections that are resistant to antibiotics, such as those caused by ...

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Blood signatures to diagnose infection
( Society for General Microbiology ) Coughing and wheezing patients could someday benefit from quicker, more accurate diagnosis and treatment for respiratory infections such as flu, through a simple blood test, according to scientists.

으로부터 유용 유전자를 확보하였으며 이를 통해 인디루빈 indirubin 테라진 A B terragiene A and B 과 같은 신규 생리활성 물질을 발견하였다 11 그림2 메타게놈 스크리닝 과정 A 다양한 환경으로부터 유전체 추출 및 제한효소 처리에 의해 메타게놈 다양성의 조사 B 유용 효소를 생산

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SCHAUMBURG, Ill.--(BUSINESS WIRE)--Proactive Worldwide, Inc., a leader in providing customized business intelligence research and consulting services, announces today that Donald J. Wyma, PhD, has joined Proactive Worldwide as Senior Engagement Manager for the company’s life sciences/healthcare practice. With a PhD in microbiology and immunology, Dr. Wyma adds a wealth of experience to the ...

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